H. pylori CagA Antigen, 0.5 mg

H. pylori CagA Antigen, 0.5 mg

Product Code: 21231222
Availability: In Stock
$199.00
Ex Tax: $199.00
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H. pylori CagA Antigen

Cytotoxin associated geneA (CagA) is one of the 31 putative genes in cag pathogenicity island (PAI) and only exists in one subgroup of H. pylori. This 40-kb segment is incorporated into the H. pylori genome via horizontal transfer. CagA can then translocate from H. pylori into H. pylori-attached gastric epithelial cells via the bacterial type IV secretion system. This allows for the manipulation of many host cellular functions including cytoskeletal function, cell-to-cell adhesion, and intracellular signal transduction. This myriad of activities and interactions promote host cell ulceration and malignancy. 

CagA protein Product Information

Protein Construction:

A DNA sequence spanning two exotoxin domain 1 and domain 2 of H. pylori cagA gene (AB015416.1) was expressed, with a H-terminal polyhistidine tag

Source:

H. pylori

Expression Host:

E. coli

CagA Protein QC Testing

Purity:

> 80 % as determined by SDS-PAGE

SDS-PAGE:

H. pylori CagA
       CagA protein

Stability:

Samples are stable for up to twenty four months from manufacture date of receipt at -70

Molecular Mass:

The recombinant CagA protein comprises of 554 amino acids with a predicted molecular mass of 61 kDa.

Formulation:

In sterile PBS, pH 7.4, with 0.02% sodium azide.

CagA Protein Usage Guide

Storage:

Store it under sterile conditions at -70. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution:

A hardcopy of the COA with reconstitution instructions is sent along with the products. Please refer to it for more detailed information.

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