Lipoprotein-associated phospholipase A2, also known as platelet-activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases. Lp-PLA2 is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib). In human atherosclerotic lesions, 2 main sources of Lp-PLA2 can be identified, including that which is brought into the intima bound to LDL (from the circulation), and that which is synthesized de novo by plaque inflammatory cells (macrophages, T cells, mast cells).
It is used as a marker for cardiac disease.
Formulation: Liquid, supplied in PBS buffer, pH 8.0, containing 0.05% sodium azide.
Applications: Excellent for use as a control or calibrator.
Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.
Source: Human plasma.
Concentration: 1 mg/mL.
Storage & Stability: Stable at 4°C for shipping purposes and short term storage.
Upon receipt, store at -20°C. After reconstitution, store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
GeneScan Diagnostics (GDX, parent company of America Diagnosis, Inc.) operates under the ISO9001 quality management system on site to ensure that our products have reliable quality and high customer satisfaction. GDX voluntarily follows ISO 13485 Quanlity Standard for manufacturing IVD devices.