Lipoprotein-associated phospholipase A2, also known as platelet-activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases. Lp-PLA2 is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib). In human atherosclerotic lesions, 2 main sources of Lp-PLA2 can be identified, including that which is brought into the intima bound to LDL (from the circulation), and that which is synthesized de novo by plaque inflammatory cells (macrophages, T cells, mast cells).
It is used as a marker for cardiac disease.
Formulation: Liquid, supplied in PBS buffer, pH 8.0, containing 0.05% sodium azide.
Applications: Excellent for use as a control or calibrator.
Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.
Source: Human plasma.
Concentration: 1 mg/mL.
Storage & Stability: Stable at 4°C for shipping purposes and short term storage.
Upon receipt, store at -20°C. After reconstitution, store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
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